| Effect of infectious bursal disease virus infection on pathogenesis of necrotic enteritis in chicken |
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Hong-jib Kim1, Mun-il Kang2, Un-ik Chung1 |
1Miwon Institute of Animal Science
2College of Veterinary Medicine, Chonnam National University |
| Infectious bursal disease virus 감염이 닭 괴사성 장염의 병원성에 미치는 영향 |
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김홍집1, 강문일2, 정운익1 |
1(주) 미원 축산과학연구소
2전남대학교 수의과대학 |
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| Abstract |
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For understanding the role of infectious bursal disease virus(IBDV) to the pathogenesis of necrotic enteritis due to Clostridium perfringens(CP), all 15 day-old chickens used were divided as the following groups; A and E group with the feeding of feed contaminated with CP, B group with oral adminstration of IBDV($50{mu}l/head$, $10^{3.4}EID_{50}$ of $P_4$ strain) and simultaneously feeding of feed contaminated with CP, C group treated with IBDV alone, F group with the feeding of feed contaminated with CP at 3 weeks after oral inoculation of IBDV, D and G group with the feeding of normal feed as controls. In mortality, B group(30%) was not a difference compared to A group(20%)(p>0.05), but in the pathological lesions the former was more severe degree than the latter. The mortality of F group(70%) was a significant difference to those of A, B or E group (20%)(p<0.01). Also, showed much F group more marked lesions than A, B or E group. In the chickens occurred the death during the study, mean concentration of CP was reached at $10^8{sim}10^9CFU/g$ in the intestinal contents. B group showed higher mortality and more severe pathological changes than A and E group. Consequently, the results in the study were confirmed that the IBDV could be a role as a enhancing factor in pathogenesis of necrotic enteritis due to CP under the field condition. |
| Key Words:
infectious bursal disease, pathogenesis, necrotic enteritis, Clostridium perfringens |
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