Antibacterial efficacy and safety of copper sulfate pentahydrate to cultured fish

Heo, Gang-joon

Korean Journal of Veterinary Research 1997;37(1):203-212.

Laboratory of Aquatic Animal Diseases, Department of Veterinary Medicine, College of Veterinary Medicine, Chungbuk National University

양식 어류에 있어서 황산동(copper sulfate pentahydrate)의 안전성과 살균효과에 대한 연구

허강준

충북대학교 수의과대학 수의학과 어류질병학연구실

Abstract

Antibacterial efficacy and safety of copper sulfate pentahydrate (5% solution) was evaluated in laboratory and field studies for disinfection of some fish bacterial pathogens in cultured fish, flounder(Paralichthys olivaceus), mirror carp(Cyprinus carpio), gold fish(Carrassius auratus) and eel(Anguilla japonica). Dipping of fishes for acute toxicity was performed for a period of 48h, and the TLm value(median tolerance limit) were 4.0ppm in mirror carp and flounder, 4.4ppm in rainbow trout, and 10.0ppm in gold fish. After exposure below than TLm value for 1 month, no side effects and histopathological changes were observed. The test drug were shown high antibacterial activities against most bacterial pathogens by exposure in the laboratory and field trials. However, Aeromonas salmonicida showed a resistance to the dosage. We can prevent outbreaks of bacterial diseases of fish by the dosage of 1ppm for 6hr and the test drug is thought to be used effectively and widely as a disinfectant against most bacterial fish pathogens.

Key Words: copper sulfate pentahydrate, antibacterial efficacy, safety, fish bacterial pathogens, cultured fish