Korean Journal of Veterinary Research 1997;37(2):457-462.
Effects of continuous administration of Tiletamine-zolazepam in dogs
Myeong-ho Park1, Kang-moon Seo2, Kwang-ho Jang3
1Wul Sung Animal Clinic
2Department of Veterinary Medicine, Kangwon National University
3Ho Am Animal Clinic
개에서 Tiletamine-Zolazepam의 연속투여가 생체에 미치는 영향
박명호1, 서강문2, 장광호3
1월성가축병원
2강원대학교 수의학과
3호암동물병원
Abstract
The effects of continuous administration of tiletamine-zolazepam(T-Z) on the blood, liver and kidney of dogs were evaluated. The drug was repeatedly administered into ten mongrel dogs intramuscularly at dose of 10mg/kg for every seven days. Hematology(PCV, WBC, RBC, TP, Fibrinogen) and serum chemistry(ALT, AST, BUN, Creatinine) were monitored for 14 days postinjection. No significant changes in PCV values, total RBC counts and plasma total protein values was found. Total WBC counts and fibrinogen values were significantly increased from 2 days to 7 days postinjection. There was no significant change in ALT, AST, BUN and creatinine levels. All animals were euthanized and necropsied at 14 days postinjection. No gross lesion and pathologic lesion was found on liver and kidney in necropsy finding.
Key Words: tiletamine-zolazepam, toxicity, dog


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