Korean Journal of Veterinary Research 1997;37(3):595-599.
Efficacy of closantel against Fasciola hepatica in experimentally-infected rats
Jong-taek Kim1, Chung-gil Lee2, Shin-hyeong Cho2
1Department of Veterinary Medicine, Kangwon National University
2College of Veterinary Medicine, Chonnam National University
랫트에 인공감염된 간질(Fasciola hepatica)에 미치는 closantel의 구충효과
김종택1, 이정길2, 조신형2
1강원대학교 축산대학 수의학과
2전남대학교 수의과대학
Abstract
Male and female Sprague-Dawley rats 8 weeks of age were inoculated per os with 10 Fasciola hepatica metacercariae each. After the infection was verified by fecal examination, they were divided into four groups at 14 weeks post-inoculation; three groups were dosed orally at 10, 20 and 30mg/kg of closantel($Flukiver^{TM}$), a salicylanilide compound and the rest used as untreated control. Efficacy of closantel was monitored weekly by fecal examination of all infected animals starting during the second week post-treatment(PT) and continuing for three weeks. Closantel elicited 96.0, 86.9 and 87.4% efficacy in rats treated with 10mg/kg at the second, third and fourth week PT, respectively. It elicited a 100% efficacy in rats treated with 20 and 30mg/kg.
Key Words: Fasciola hepatica, rat, closantel, egg counts


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