Korean Journal of Veterinary Research 1997;37(3):619-627.
Effects of red ginseng total saponin on Menadione-induced hepatotoxicity in the rat
Bong-jun Jang1, Chun-sik Bae1, Yong-seong Cho1, Yong-ho Cha2, Chang-won Park3, Tae-hyun Cho3, Kyung-jin Chang1
1Department of Veterinary Medicine, College of Animal Husbandry, Kon-Kuk University
2Sang-Ju National Polytechnique University
3Korea Food and Drug Administration
Menadione에 의해 유발된 간독성에 미치는 홍삼사포닌의 영향
장봉준1, 배춘식1, 조용성1, 차용호2, 박창원3, 조대현3, 장경진1
1건국대학교 축산대학 수의학과
2상주산업대학교
3식품의약품안전본부
Abstract
It is known that 2-methyl-1,4-naphtoquinone(menadione, MD) induces hepatotoxicities both in vivo and in vitro. These toxic effects are believed to result from oxidative damages to hepatocytes by "active oxygen" species via one-electron reduction of the naphtoquinone. The ginsenoside(GS) is a complex mixture of individual ginsenosides which is known to produce a range of effects on the cardiovascular and central nervous systems. In particular, GS has an antioxidant effect. In this experiment we studied the effect of GS from red panax ginseng(red ginseng total saponin, RGTS) on free radical-induced liver injuries by MD. Administration of MD($150{mu}M$) caused an increase in aspartate aminotransferase(AST) activities and lipid peroxidation, decrease in alkaline phosphatase(ALP) activities and total bilirubin levels in blood, caused depletion of GSH and changes of antioxidant enzyme(superoxide dismutase, catalase) activities are shown in liver tissue. Administration of RGTS restored the AST levels that increased by MD, but catalase showed no significant changes. RGTS also had an effect of restoring the GSH level and had some synergistic effects with SOD. These data suggest that RGTS may have some protective effects on liver injury which is related with the oxygen free radical.
Key Words: menadione, liver, toxicity, ginsenoside, antioxidant effect


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