Korean Journal of Veterinary Research 1997;37(4):719-726.
Distribution of neuropeptide-immunoreactive cells of calcitonin gene-related peptide and substance P in the lumbar dorsal root ganglia of WKY rat
Jae-won Shin1, Yeo-sung Yoon1, Moo-ho Won2, Yang-seok Oh3
1Department of Veterinary Medicine, Kangwon National University
2Department of Anatomy, College of Medicine, Hallym University
3Experimental Animal Center, College of Medicine, Hallym University
WKY 랫드 요수부분 척수신경절 내에서 Calcitonin gene-related peptide와 Substance P 면역반응세포의 분포
신재원1, 윤여성1, 원무호2, 오양석3
1강원대학교 수의학과
2한림대학교 의과대학 해부학교실
3한림대학교 의과대학 실험동물부
Dorsal root ganglion(DRG) cells are primary sensory neurons which contain some biologically active neuropeptides which play a role as neurotransmitters or neuromodulators. This study was performed to observe normal distribution of calcitonin gene-related peptide (CGRP) and substance P (SP) immunoreactive cells and colocalization of CGRP and SP in a single DRG cell of the lumbar DRGs($L_1{sim}L_6$) in the Wistar Kyoto(WKY) rat by immunohistochemistry. About 55.8% of DRG cells contained CGRP-immunoreactivity, while about 12.7% of DRG cells showed SP-immunoreactivity. There was no significant difference in percentage of each neuropeptied-immunoreactive cells between each neuropeptide-immunoreactive cells between each levels of DRGs ($L_1{sim}L_6$) (p>0.01). In size distribution, CGRP-immunoreactive cells were identified below $1,500{mu}m^2$; SP-immunoreactive cells below $600{mu}m^2$. In serial sections, about 86.7% of the SP immunoreactive cells contained CGRP immunoreactivity.
Key Words: calcitonin gene-related peptide (CGRP), substance P (SP), colocalization, immunohistochemistry, lumbar dorsal root ganglion(DRG)

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