Pathological studies on the hepatic fibrosis induced by Capillaria hepatica

Shin, Eun-kyung; Han, Jeong-hee

Korean Journal of Veterinary Research 1998;38(1):119-128.

Eun-kyung Shin, Jeong-hee Han

Department of Veterinary Medicine, Kangwon National University

마우스에서 Capillary hepatica 감염에 의한 간섬유증의 병리학적 연구

신은경, 한정희

강원대학교 수의학과

Abstract

This study was performed to investigate the pathogenesis of hepatic granuloma and hepatic fibrosis induced in mice infected with Capillaria(C) hepatica and treated cyclophosphamide. The results were as grossly well-defined yellowish white spots and small nodules at the surface of the liver were scattered. Histopathologically, there were numerous granulomas composed of eggs and fragments of C hepatica surrounded by heavy infiltration of inflammatory cells. Severe fibrosis was observed around granulomas. Pathological lesions of group infected with C. hepatica and then injected with cyclophosphamide were most severe than those of other groups. Therefore this study suggested that hepatic fibrosis induced by C hepatica in mice would be useful for animal model of hepatic fibrosis in human.

Key Words: Capillaria hepatica, cyclophosphamide, granuloma, hepatic fibrosis