Korean Journal of Veterinary Research 1998;38(2):319-327.
Sequence of the spike gene containing antigenic sites A and D of transmissible gastroenteritis virus isolated in Korea
Hyuk-moo Kwon1, Jae-ho Pi1, Hwan-woo Seong2
1Department of Veterinary Medicine, Kangwon National University
2National Veterinary Research Institute
국내분리 돼지 전염성 위장염 바이러스의 antigenic site A와 D를 포함하는 spike gene의 염기서열 분석
권혁무1, 피재호1, 성환우2
1강원대학교 수의학과
2수의과학연구소
Abstract
The nucleotide sequences of spike (S) glycoprotein containing antigenic sites A and D of TGEV isolated in Korea were determined and compared with published sequences for TGEVs. The TGEV 133 and DAE5 strains had 97.40% nucleotide sequence similarity. The overall nucleotide sequence similarity of the 133 and DAE5 strains compared with other TGEV strains was between 96.86% and 99.15%. The similarity of the predicted amino acid sequence of the 133 and DAE5 strains was 94.93%. The TGEV 133 and DAE5 strains had 94.93-98.61% amino acid similarity with published sequences of other TGEV strains. The sequences of amino acid codons in the antigenic sites A and D were identical among all the viruses although there were several nucleotide changes in region containing antigenic sites A and D of Korean TGEV isolates. By phylogenetic analysis of the sequences, two Korean isolates 133 and DAE5 seemed to be derived from different lineages. These studies showed that a distinct difference in genome exists among TGEV field strains isolated in Korea.
Key Words: TGEV, coronavirus, spike glycoprotein gene, sequencing


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