Study on clinico-pathological and ultrasonographic changes for experimental induced-acute pancreatitis in dogs

Yun, Young-min; Park, Su-jin; Yoon, Jung-hee; Youn, Hwa-young; Choi, Hee-in

Korean Journal of Veterinary Research 1998;38(2):423-435.

Young-min Yun, Su-jin Park, Jung-hee Yoon, Hwa-young Youn, Hee-in Choi

College of Veterinary Medicine, Seoul National University

개에서 실험적으로 유발시킨 급성 췌장염에 있어서 혈액화학치와 췌장의 초음파학적 변화

윤영민, 박수진, 윤정희, 윤화영, 최희인

서울대학교 수의과대학

Abstract

In acute pancreatitis group, all the dogs are showed increase of amylase and lipase after the 1st day of surgery, and amylase and lipase activity were significantly more increased than those of control group. The methemalbumin was increased significantly after the 2nd day of surgery in the acute pancreatitis group. In pancreatitis group, ultrasonographic findings included thickened duodenal wall and poorly circumscribed hyperechoic lesion of pancreatic mass after the 2nd day of surgery. And the lesion was exacerbated until the 4th day and reduced after the 6th day of surgery. To identify the lesion of pancreas, it is considered that transverse view is more useful Than sagittal view. Gross findings showed increase of pancreatic parenchymal consistency, surface nodule, and extensive pancreatic necrosis. Necrosis of peripancreatic fat tissue was also a prominent feature. The microscopic appearance of the pancreas was characterized by pancreatic acinar cell necrosis, hemorrhage, infiltration of the inflammatory cell and fat necrosis and saponification were also observed.

Key Words: acute pancreatitis, amylase, lipase, ultrasonography, dog