Korean Journal of Veterinary Research 1998;38(4):867-881.
The clinical physiopathological changes by induction of hypothermia in rabbits
Byeong-han Lee1, Jin-soo Han2, Byung-hyun Chung1
1School of Veterinary Medicine, Kon-Kuk University
2Samsung Biomedical Research Institute
토끼에서 저체온증의 유발에 의한 생리학적 및 임상병리학적 변화
이병한1, 한진수2, 정병현1
1건국대학교 수의학부
The studies were carried out to investigate the phygiological changes in deep hypothermia in rabbits. Sixty rabbits were continuously cooled with femoral arterio-venous bypass circulation to rectal temperatures of $34.0{pm}0.3^{circ}C$(mild hypothermia), $30.0{pm}0.3^{circ}C$(moderate hypothermia), and $25.0{pm}0.3^{circ}C$(deep hypothermia). The results obtained in these experiments were summarized as follows : In mild, moderate, and deep hypothermia, MAP, HR, RR, pH, $pCO_2$, $pO_2$, $Na^+$, $K^+$, HCT, PLT, glucose, L-lactate, BUN, and creatinine were analyzed. During hypothermia, a statistically significant decrease of MAP occurred between $30^{circ}C$ and early $25^{circ}C$(Start) of rectal temperature while significant increases occurred between baseline($38.7^{circ}C$) and $30^{circ}C$. Significant decreases of HR and RR were observed in the rabbits, particularly those changes appeared to similar patterns in proportion to hypothermia. Significant decreases of pH occurred between $34^{circ}C$ and $25^{circ}C$, and significant increases of $pO_2$ and $pCO_2$ were observed continuously in the hypothermic rabbits. The hypothermia had no significant effect on blood $Na^+$ and serum creatinine. Blood $K^+$ significantly decreased from $3.1{pm}0.5$(baseline) to $2.6{pm}0.6mmol/l$($34^{circ}C$) with the hypothermia for about 30 minutes, and significantly increased from $2.4{pm}0.6$($25^{circ}C$(S)) to $2.7{pm}0.5mmol/l$($25^{circ}C$(E)) with the hypothermia for 2 hrs. HCT significantly increased to $34^{circ}C$, thereafter, continuously increased to $25^{circ}C$(Start, End). PLT increased to $34^{circ}C$, thereafter, continuously decreased to $25^{circ}C$(Start, End). Also PLT decreased significantly from 414.3($30^{circ}C$) to $308.8{ imes}103/mm^3$($25^{circ}C$, Start). Significant increases of blood glucose and L-lactate occurred between $30^{circ}C$ and $25^{circ}C$ (Start, End). Slight increase of serum BUN continuously appeared with the hypothermia. These results, such as characteristic changes of the significant decrease of pH and PLT at $34^{circ}C$, the significant decrease of MAP at $30^{circ}C$, and the significant increase of glucose and l-lactate at $30^{circ}C$, suggest that homeostasis of rabbits to hypothermia rapidly decreases at $34{sim}30^{circ}C$ of rectal temperature. Therefore, we suggest that, during the period with the rapidly decreased homeostasis, the very carefully control and treatment need to recover hypothermic animals under the circumstances of the various hypothermic experiments and emergency medicine.
Key Words: hypothermia, rabbit, hematology, blood chemistry, electrolyte

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