| Dissemination of Borrelia burgdorferi and immunological responses after experimental infection in rabbits |
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Jong-bae Kim, Sung-un Park, Hye-wone Song, Sang-wook Park, Young-mi Kim |
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Department of Medical Technology, College of Health Science, Yonsei University |
| 실험적으로 감염시킨 토끼에서 Borrelia burgdorferi 분포 및 면역반응 양상 |
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김종배, 박성언, 송혜원, 박상욱, 김영미 |
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연세대학교 보건과학대학 임상병리학과 |
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| Abstract |
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The visceral dissemination of Borrelia burgdorferi in New Zealand White rabbits was evaluated following intradermal inoculation of $1{ imes}10^8$ spirochetes. We inoculated Borrelia burgdorferi B31, B garinii KW1 and B afzehlii S13, respectively, and monitored the dissemination in the experimentally infected rabbits for 28 days. In the B burgdorferi B31-challenged group, the spirochetes were completely cleared in rabbits at day 1 and visceral dissemination was not demonstrated. However, B garinii KW1 and B afzelii S13 were found to successfully disseminate in visceral organs of rabbits during the experiment period of 28 days. And experimentally infection-derived immunological responses in rabbits were identified with enzyme-linked immunosorbent assay and immunoblot analysis. Based on these results, the differences in the virulence of Lyme borrelial strains were proved in rabbit model. |
| Key Words:
Borrelia burgdorfen, Lyme borreliosis, dissemination, immunological response |
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