| Localizations of substance P, CGRP and calcium binding proteins in Korean native goat duodenum |
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In-se Lee1, Heungshik S. Lee1, Seung-hoon Song1, Sung-tae Yoon1, In-koo Hwang1, Tae-cheon Kang2, Moo-ho Won2, Je-hoon Seo3 |
1College of Veterinary Medicine, Seoul National University
2College of Medicine, Hallym University
3College of Medicine, Seoul National University |
| 한국재래산양 십이지장의 장관신경계통에 분포하는 Substance P, CGRP 및 칼슘결합단백질 반응세포에 대한 면역조직화학적 연구 |
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이인세1, 이흥식1, 송승훈1, 윤성태1, 황인구1, 강태천2, 원무호2, 서제훈3 |
1서울대학교 수의과대학
2한림대학교 의과대학
3서울대학교 의과대학 |
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| Abstract |
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The localization of substance P(SP), calcitonin gene-related peptide(CGRP) and three calcium binding proteins, calbindin D-28k(CB), calretinin(CR) and parvalbumin(PA) was immunohistochemically examined in the myenteric and submucous plexuses of Korean native goat duodenum. In the neurons of myenteric and submucous plexuses of duodenum, immunoreactivities of SP, CGRP and CB were confirmed in both nerve cell bodies and fibers. In contrast, CR immunoreactivity was found only in nerve fibers of myenteric plexuses, while PA immunoreactivity was found only in nerve cell bodies of submucous plexuses. In the inner circular muscle layer, dense SP-like immunoreactive fibers were prominent but only a few CGRP-like immunoreactivities were observed. Most of SP- and CGRP-like immunoreactive neurons of both plexuses colocalized with CB. This result showed that SP and CGRP may have a important role for the movement of small intestine. The colocalizations of CB with SP or CGRP in myenteric and submucous plexuses suggest that CB may serve neuromodulatory role for SP- and CGRP-immunoreacted neurons on the movement of intestinal wall. |
| Key Words:
substance P, CGRP, calcium binding protein, duodenum, immunohistochemistry |
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