Korean Journal of Veterinary Research 1999;39(3):635-644.
Effects of Isoprothiolane administration on fat necrosis of Hanwoo(Korean Cattle) sire
Seoung-soo Lee1, Yeoun-su Lim1, Joon Jeong1, Yun-ho Jang1, Jong-kwan Park1, No-hyoung Park1, You-seog Won1, Sang-keun Kim2
1Hanwoo Improvement Center, NLCF
2Department of Verterinary Medicine, Chungnam National University
한우 종모우의 지방괴사증에 대한 Isoprothiolane 투여효과
이성수1, 임연수1, 정준1, 장윤호1, 박종관1, 박노형1, 원유석1, 김상근2
1축협중앙회 개량사업본부 한우개량부
2충남대학교 수의과대학
The effect of isoprothiolane(di-isopropyl-1,3-dithiolan-2-ylidenemalonate) aganist fat necrosis in Hanwoo(Korean Cattle) sire was evaluated. The 10 heads of Hanwoo sire suffering from fat necrosis were given 50mg/kg body weight of isoprothiolane(0.2g/kg of Fujix, Japan) orally once a day for 8 weeks. In 30% of these, the size of the necrotic fat masses had decreased significantly 7 months after the adminstration. Isoprothiolane did not affect on live body weight and semen characteristics. However the sire affected with fat necrosis had higher MCHC(Mean corpuscular hemoglobin concentration) than normal sire in hematologic values 10 weeks after administration. Number of RBC(red blood cell) and PCV(packed cell volume) 10 weeks after administration had been increased than those before administration(p < 0.05). The serum concentrations of creatinine, triglyceride, and total cholesterol 10 weeks after administration were higher than those before administration while the concentration of glucose was vice versa. The isoprothiolane may reduce the oxidation of glucose, increase the glucose transfer to lipids, and increase blood supply to necrotic masses. These results indicate that isoprothiolane may be useful as the therapeutic agent aganist fat necrosis.
Key Words: isoprothiolane, Hanwoo(Korean Cattle), fat necrosis

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