| Effect of anesthetics and diuretics on Doppler measurements of intrarenal resistive index in dogs |
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Ho-jung Choi1, Jung-hee Yoon1, Ki-dong Eom2, Hee-chon Lee1, Ji-hye Choi1, Jae-ki Sung1 |
1College of Veterinary Medicine, Seoul National University
2Yongma Animal Hospital |
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| Abstract |
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lntrarenal resistive index (RI) was determined in normal, sedated and diuretic kidneys. The mean RI values of normal dogs were $0.64{pm}0.03$ without statistically significant difference between left and right kidney. Interrenal RI difference (${Delta}RI$) was $0.03{pm}0.01$. No significant relationship was found between mean intrarenal RI versus body weight. The mean intrarenal RI values after administration of acepromazine, xylazine, thiopental, and ketamine were $0.66{pm}0.03$, $0.64{pm}0.03$, $0.56{pm}0.05$, and $0.50{pm}0.05$, respectively. After administration of acepromazine or xylazine, a significant change of the RI was not found. But, a significant decrease of the RI following thiopental or ketamine administration could be observed as compared with the normal RI. The mean intrarenal RI values were $0.63{pm}0.06$ and $0.62{pm}0.04$ at 10 minutes and 30 minutes after injection of furosemide, respectively. No significant change of intrarenal RI was found after administration of furosemide. But, mannitol significantly decreased mean intrarenal RI to $0.57{pm}0.02$ and $0.58{pm}0.03$ at 30 minutes and 60 minutes, respectively. Based on the obtained results, values of 0.72 and 0.05 may be proposed as the reasonable upper limits of RI and ${Delta}RI$ of normal average. Acepromazine or xylazine are recommended as anesthetics for renal diseases because they have less effect on the RI. Further study using mannitol injection to increase ${Delta}RI$ may be suggested in unilateral urinary tract obstruction since mannitol more effectively changed mean RI than furosemide. |
| Key Words:
resistive index, anesthetics, diuretics, Doppler, dog |
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