| Effects of forskolin on secretion of insulin like growth factor-I in the perfused rat liver model |
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Chang-won Kang1, Dae-yeol Lee2, Ho-il Lee1 |
1Bio-Safety Research Institute, Chonbuk National University
2Department of Pediatrics, Chonbuk National University Medical School |
| 백서 간 관류모델에서 forskolin이 Insulin like growth factor-I의 분비에 미치는 효과 |
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강창원1, 이대열2, 이호일1 |
1전북대학교 생체안전성연구소
2전북대학교 의과대학 소아과학교실 |
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| Abstract |
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The insulin-like growth factor-I(IGF-I) is an important metabolic factor involved in cell growth and metabolism. Although secretion of IGF-I in rat liver is regulated by growth hormone, the effects of forskolin, adenylate cyclase activator, on secretion of IGF-I have not been reported. Therefore, a modified perfused rat liver model was used to investigate the regulatory effects of forskolin on IGF-I secretion in this experiment. The results were summerized as follows : 1. Modified perfused rat liver model was not changed to aspartate aminotransferase(AST), alanine aminotransferase(ALT) and lactic dehydrogenase(LDH) secretion in time. 2. The IGF-I secretion in hepatic cell was increased by forskolin($10^{-5}$, $10^{-6}$ and $10^{-7}M$) in a dose-dependent manner as compared with those of the controls, and significantly increased by $10^{-5}$ and $10^{-6}$ forskolin(p < 0.05). 3. Secretion of glucose in hepatic cell significantly was decreased by $10^{-5}$ forskolin as compared with those of controls(p < 0.05). These results suggest that forskolin may be involved in the regulation of IGF-I secretion in the perfused rat liver. |
| Key Words:
IGF-I, forskolin, liver, cAMP |
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