| Characteristics of Pasteurella multocia isolated from pneumonic lung lesions of swine ; antimicrobial susceptibility, plasmid profile and distribution of toxA |
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Na-ri Shin, Joo-youn Park, Yong-ho Park, Han-sang Yoo |
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College of Veterinary Medicine, Seoul National University |
| 돼지 폐렴병소로부터 분리한 Pasteurella multocida에 관한 연구 : 항균제 감수성, plasmid profile 및 toxA 유전자 분포 |
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신나리, 박주연, 박용호, 유한상 |
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서울대학교 수의과대학 |
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| Abstract |
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Antimicrobial susceptibility, plasmid profiles and distribution of toxA gene were investigated in Pasteurella multocida isolated from pneumonic lung lesions of swine. The bacteria were highly susceptible to norfloxacin, cabenicillin, enrofloxacin and chloramphenicol, but resistant to colistin, sulfamethoxawle/trimethoprime, bacitracin, streptomycin. Sixty percentage of the isolates was resistant more than 2 drugs used in this experiment and 21 strains (23.6%) were resistant more than 5 drugs. This phenomenon meant that they had highly multi-drugs resistance. In the analysis of plasmid profiles, nineteen strains (47.5%) of 40 P multocida isolates harbored plasmids, ranging from 53.3kb to 2.49kb in size and the plasmid profiles could be classified into 5 groups. However, there was no relationship between the size and the profile of plasmid and the resistance pattern of antimicrobial agents. Thirty strains of 39 P multocida isolates (77%) investigated by PCR harbored toxA gene. This result suggested involvement of the ToxA protein expressed from the gene in pneumonic pasteurellosis of swine. |
| Key Words:
Pasteurella multocida, Antimicrobial susceptibility test, Plasmid profile, toxA gene |
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