Korean Journal of Veterinary Research 1999;39(6):1168-1179.
Histological and immunohistochemical effects of Jengjengamiyjintang on the duodenal ulcer induced by HCl-aspirin
Sae-kwang Ku1, Hyeung-sik Lee2, Jae-hyun Lee3
1Parmacol & Toxicol Lab., Central Research Laboratories, Dong-Wha Pharm. Ind. Co.
2Department of Biology, Faculty of Basic Science, Kyungsan University
3Laboratory of Histology, College of Veterinary Medicine, Kyungpook National University
정전가미이진탕이 HCl-aspirin으로 유발된 십이지장 궤양에 미치는 조직학적 및 면역조직화학적 연구
구세광1, 이형식2, 이재현3
1(주)동화약품 중앙연구소 약리독성 연구실
2경산대학교 기초과학부 생물학전공
3경북대학교 수의과대학 조직학교실
In order to study the effects of Jengjengamiyjintang on the duodenal ulcer induced by HCl-aspirin in rats, the changes of histological profiles, goblet cells(PAS-positive cells), and the distribution and frequency of cholecystokinin(CCK)-8 and serotonin-producing gastro-entero-endocrine cells were observed after oral administration of Jengjengamiyjintang. Histologically, very severe injury to duodenal epithelium were observed in control groups and these injuries were increased with time intervals. But in the Jengjengamiyjintang administrated groups, no gross lesion of ulcer were demonstrated and histologically minor injury to the mucosal epithelium were observed. PAS-positive cells were increased in the Jengjengamiyjintang administrated groups compared to that of control groups. Severe degranulation of CCK-8- and serotonin-immunoreactive cells were observed in control groups but these phenomenon was seldom in the Jengjengamiyjintang administrated groups. Serotonin-immunoreactive cells were significantly decreased in control groups but increased in Jengjengamiyjintang administrated groups compared with control groups. According to these result, it is suggested that Jengjengamiyjintang would accelerat the healing of the duodenal ulcer but the functional mechanisms were unknown.
Key Words: duodenal ulcer, histology, jengjengamiyjintang, serotonin, CCK-8, immunohistochemistry

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