Experimental infection of Korean Neospora caninum isolates in mice

Bae, Ji-seon; Kim, Jae-hoon; Hur, Kwon; Kim, Ki-suk; Hwang, Woo-suk; Choi, Yang-kyu; Hyun, Byung-hwa; Kim, Dae-yong

Korean Journal of Veterinary Research 2000;40(1):138-144.

Ji-seon Bae¹, Jae-hoon Kim², Kwon Hur¹, Ki-suk Kim², Woo-suk Hwang¹, Yang-kyu Choi³, Byung-hwa Hyun³, Dae-yong Kim¹

¹College of Veterinary Medicine, Seoul National University
²National Veterinary Research and Quarantine Service
³Korea Research Institute of Bioscience and Biotechnology

Neospora caninum 국내 분리주의 마우스 감염실험

배진선¹, 김재훈², 허권¹, 김기석², 황우석¹, 최양규³, 현병화³, 김대용¹

¹서울대학교 수의과대학
²국립수의과학검역원
³생명공학연구소

Abstract

This study was carried out to investigate the pathogenicity of Korea N caninum isolates, KBA-1 and KBA-2 on SCID mouse following 3 different routes of infection. NC-1 was served as reference isolate. The pathogenecity was evaluated by progression of clinical signs, histopathology and immunohistochemistry. Pathogenicity of KBA-2 appears to be stronger than that of KBA-1 but weaker than that of NC-1. Progress of clinical signs and lesion distribution and pattern of each isolates were similar when the isolates were infected either subcatareously or intraperitoneally. However, oral inoculation of tachyzoites failed to induce the infection.

Key Words: Neospora caninum, SCID mice, infection, pathogenicity