Korean Journal of Veterinary Research 2000;40(2):311-323.
Immunosuppressive effects and pathogenicity of a Korean isolate of reticuloendotheliosis virus in chickens
Myung-guk Han1, Sun-joong Kim2
1Avian Disease Division, National Veterinary Research and Quarantine Service
2College of Veterinary Medicine, Seoul National University
Reticuloendotheliosis virus의 닭에 대한 면역억제효과와 병원성
한명국1, 김선중2
1국립수의과학검역원 조류질병과
2서울대학교 수의과대학 조류질병학교실
Abstract
Immunosuppressive effects of reticuloendotheliosis virus (REV) infection in chickens were investigated. Primary antibody responses to Newcastle disease virus (strain B1) and sheep red blood cells were significantly low in chickens inoculated with the local isolate 89-74 of REV compared to those of uninfected chickens. In chickens infected with REV strain T or 89-74, blastogenesis of spleen cells and peripheral blood lymphocytes (PBL) to concanavalin A (Con A) was severely suppressed. When specific pathogen free (SPF) chickens were inoculated with the isolate, the suppressive effect was observed up to 7 weeks of age while, in the contact infected chickens, the suppression was absent. Similar suppressive effects were observed in chickens inoculated with REV strain T at 2, 3 and 4 weeks of age. When spleen cells or PBL from uninfected chickens were co-cultured with spleen cells or PBL from chickens infected with REV at 1 day-old or 2 week-old, the blastogenesis of the normal cells was suppressed. The suppressive effect of PBL from REV-infected chickens on normal lymphocytes was abrogated by the treatment with trypsin. However the suppressive activity of the REV-infected PBL was not influenced at removing machrophage from the cell suspension by incubation in plastic petri dishes. In addition to the immunosuppression, chickens infected with the REV isolate showed abnormal feather development (nakanuke), anemia, paralysis and retarded growth. Three out of 11 chickens inoculated with the isolate at day-old died between 6 and 9 weeks of age by bacterial infections.
Key Words: reticuloendotheliosis virus, immunosuppression, blastogenesis, pathogenicity


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