Changes of spontaneous pancreatic exocrine secretion during the estrous cycle in rats

Park, Hyung-seo; Lee, Tae-im; Kim, Se-hoon; Park, Hyoung-jin; yang, Il-suk

Korean Journal of Veterinary Research 2000;40(4):677-681.

Hyung-seo Park¹, Tae-im Lee¹, Se-hoon Kim¹, Hyoung-jin Park², Il-suk yang³

¹Department of Physiology, College of Medicine, Konyang University
²Department of Physiology, College of Medicine, Hallym University
³Department of Physiology College of Veterinary Medicine, Seoul National University

흰쥐에서 발정주기에 따른 자발적인 췌장외분비의 변화

박형서¹, 이태임¹, 김세훈¹, 박형진², 양일석³

¹건양대학교 의과대학 생리학교실
²한림대학교 의과대학 생리학교실
³서울대학교 수의과대학 생리학교실

Abstract

Since the role of female sexual hormones on pancreatic exocrine secretion was not fully understood, this study was investigated to clarify the difference of spontaneous pancreatic exocrine responses during the estrous cycle and the roles of ovarian hormones on pancreatic exocrine secretion in the anesthetized female rats. Pancreatic juice was collected from the sequential 15-min samples, and then fluid and protein secretion were measured from the collected samples. The stages of estrous cycle were defined by staining the vaginal smear. The spontaneous pancreatic fluid and protein secretion were significantly increased during the diestrus stage compare to the corresponding value during the estrus stage. In the ovariectomized rat, spontaneous pancreatic exocrine secretion was significantly decreased compare to the value of female rat during the diestrus stage and was restored by subcutaneous injection of progesterone (50 mg/kg). This results suggest that the spontaneous pancreatic exocrine secretion of female rat is fluctuated according to the estrous cycle and progesterone released from ovary could stimulate the spontaneous pancreatic exocrine secretion of female rat.

Key Words: pancreatic secretion, rats, estrous cycle, ovariectomy, progesterone