Korean Journal of Veterinary Research 2001;41(1):105-111.
The radioprotective effects of radices herbs
Sung-ho Kim1, Heon Oh1, Se-ra Kim1, Sung-kee Jo2, Myung-woo Byun2, Kil-soo Kim3, Jong-hwan Lee1, Dong-ho Shin1
1College of Veterinary Medicine, Chonnam National University
2Food Irradiation Team, KAERI
3Hae-Eun Life Science Research Institute
대표적 근류 생약의 방사선 방호효과
김성호1, 오헌1, 김세라1, 조성기2, 변명우2, 김길수3, 이종환1, 신동호1
1전남대학교 수의과대학
2한국 원자력연구소 방사선 식품공학팀
3해은생명과학연구소
Abstract
We performed this study to determine the effect of Jiegeng(Platycodon grandiflorum), Danggui(Angelica sinensis), Gancao(Glycyrrhiza glabla), Chaihu(Bupleurum falcatnosa), Shoudehuang(Rehmannia glutinosa), Huangqi(Satragalus membranaceus), Muxiang(Saussurea lappa), Yuanzhi(Polygala tenuifolia), Rensen(Panax ginseng) and Baishaoyao(Paeonia lactiflolia), as Oriental radices herbs, on jejunal crypt survival, endogenous spleen colony formation and apoptosis in jejunal crypt cells of mice irradiated with high and low dose of ${gamma}-radiation$. Jiegeng(p<0.005), Danggui(p<0.0005), Gancao(p<0.005), Chaihu(p<0.05), Muxiang(p<0.05), Rensen(p<0.005) and Baishaoyao(p<0.005) were effective in intestinal crypt survival. Danggui(p<0.05), Chaihu(p<0.05), Shoudehuang(p<0.05), Huangqi(p<0.05), Rensan(p<0.005) and Baishaoyao(p<0.05) increased the formation of endogenous spleen colony. The frequency of radiation induced apoptosis was also reduced by pretreatment with Chaihu(p<0.05), Muxiang(p<0.005), Yuanzhi(p<0.05), Rensan(p<0.05) and Baishaoyao(p<0.05). Although the mechanisms of this effect remain to be elucidated, these results indicated that Danggui, Chaihu, Muxiang, Rensan and Baishaiyao might be a useful radioprotector, especially since it is a relatively nontoxic natural product.
Key Words: Danggui(Angelica sinensis), Cbaihu(Bupleurum falcatnosa), Muxiang(Saussurea lappa), Rensen(Panax ginseng), Baishaoyao(Paeonia lactiflolia), radices herbs, radioprotector


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