| Antioxidant activity of vitamin C in iron-overloaded swine plasma |
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Dongjoo Lim1, Hochul Song2, Junbong Park2 |
1Maya Trading Co. Ltd.
2Department of Veterinary Medicine, Cheju National University |
| 철분 투여한 돼지에서 비타민 C의 항산화 작용 |
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임동주1, 송호철2, 박전홍2 |
1마야무역
2제주대학교 수의학과 |
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| Abstract |
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Iron deficient anemia in piglets could be overcome by supplementary iron. Overloaded iron induced peroxidation of cell membrane and increased malonaldehyde (MDA). Antioxidant activity of vitamin C has been studied in iron-overloaded swine plasma. Erythrocyte fragility, MDA, glutathione, vitamin A, and vitamin E were measured in swine plasma with or without iron (0~1mg/dl) and vitamin C (0~10mg/dl). Erythrocyte fragility increased from 8% to 45% in iron group and reduced from 57% to 43% in vitamin C group with dose dependant response. MDA was $0.94{pm}0.05$ and $1.86{pm}0.10$ nmol/ml in piglet and pig, respectively, and significantly high in pig (p<0.05). Iron increased MDA from $1.86{pm}0.10$ to $9.46{pm}0.04$ nmol/ml in pig, but not in piglet (p<0.05). Vitamin C reduced MDA from $9.46{pm}0.04$ to $4.80{pm}0.10$ nmol/ml in pig. Iron increased glutathione from $90.12{pm}0.10$ to $108.52{pm}5.29$ nmol/dl in pig, and vitamin C reduced glutathione from $108.52{pm}5.29$ to $93.52{pm}2.44$ nmol/dl (p<0.05). Vitamin A and E were $24.86{pm}2.70$ to $138.29{pm}6.70{mu}g/dl$, respectively in iron group, and $35.76{pm}0.60$ to $177.21{pm}2.95{mu}g/dl$, respectively in supplementary vitamin C group (p<0.05). These data indicated an antioxidant activity of vitamin C in iron-overloaded swine plasma. |
| Key Words:
iron, malondialdehyde, glutathione, vitamin C, swine |
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