Korean Journal of Veterinary Research 2001;41(4):455-465.
Morphological study of GFAP-immunoreactive cells of fetal and neonatal spinal cords of Korean native goat
Chi-Won Song1, Soo-Youn Chung1, Keun-Jwa Lee2, Kang-Iee Lee3, Kyoung-Youl Lee4, Il-Kwon Park4, Mi-Sun Park4, Seung-Hyuk Chung4, Gyu-Woan Cho4, Moo-Kang Kim4
1National Toxicology Research Center
2Chungnam Institute of Livestock and Veterinary Research
3College of Oriental Medicine, Taejon University
4College of Veterinary Medicine, Chungnam Natioinal University
한국재래산양 태아 및 신생아 척수에서 GFAP 면역반응세포에 관한 형태학적 연구
송치원1, 정수연1, 이근좌2, 이강이3, 이경열4, 박일권4, 박미선4, 정승혁4, 조규완4, 김무강4
1국립독성연구소
2충남축산위생연구소
3대전대학교 한의과대학
4충남대학교 수의과대학
Abstract
Glial fibrillary acidic protein(GFAP) is one of the intermediate filaments, and used as an astrocyte detection marker. GFAP distribution has been studied on the fetal, neonatal and aged brains. In this study, the GFAP immunoreactive cell localization and distribution in the fetal (30, 45, 60, 90, 105 and 120 days of gestation) and neonate spinal cords of Korean native goat were investigated by immunohistochemistry. Nonpolar radial glial cells initiated to appear at 45 days of gestation. GFAP-immunoreactive processes were extended from central canal to pia matter. Bipolar immumoreactive cells were transformed to monopolar and multipolar immunoreactive cells at 45 days of gestation. Multipolar astrocytes of 60 days of gestation were found within white and gray matters of spinal cord. The number of GFAP-immunoreactive cells were gradually decreased from 90 days of gestation until newborn neonate. The intensity of GFAP immunoreactivity was gradually decreased from 95 days of gestation until newborn neonate. These results suggest that the radial glial cells within the gray and white matters of spinal cord are very fast developed.
Key Words: Korean native goat, GFAP, development, spinal cord


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