A Case of Natural Mycoplasmosis in Spontaneously Hypertensive Rats

Roh, In-Soon; Oh, Seung Hyun; Park, Ji Young; Choi, Kyung-Chul; Han, Jeong-Hee; Jin, Hee-Kyung; Do, Seon Gil; Suh, Jun Gyo; Oh, Yang Seok; Park, Seong-Jun; Seong, Je-Kyung

Korean Journal of Veterinary Research 2001;41(4):579-582.

In-Soon Roh¹, Seung Hyun Oh¹, Ji Young Park¹, Kyung-Chul Choi², Jeong-Hee Han³, Hee-Kyung Jin³, Seon Gil Do⁴, Jun Gyo Suh⁴, Yang Seok Oh⁴, Seong-Jun Park⁵, Je-Kyung Seong¹

¹Department of Laboratory Animal Medicine, Yonsei University College of Medicine
²Department of Biomedical Science, College of Veterinary Medicine, Cornell University
³Department of Veterinary Medicine, Kangwon National University
⁴Experimental Animal Center, College of Medicine, Hallym University
⁵Department of Veterinary Internal Medicine, Tokyo University of Agriculture and Technology

Mycoplasm pulmonis에 자연 감염된 SHR 랫드

노인순¹, 오승현¹, 박지영¹, 최경철², 한정희³, 진희경³, 도선길⁴, 서준교⁴, 오양석⁴, 박성준⁵, 성제경¹

¹연세대학교 의과대학 임상의학연구센터 실험동물부
²코넬대학교 수의과대학 생물의학과
³강원대학교 동물자원대학 수의학과
⁴한림대학교 의과대학 실험동물부
⁵동경 농공대학교 농학부

Abstract

Twenty one Spontaneously Hypertensive Rats(SHR) that were 4- to 21-month-old were examined histopathologically and serologically during a routine health monitoring of the rat colony. The results of the enzyme linked immunosorbent assay(ELISA) for murine pathogens demonstrated that 14 of 21 SHR rats had antibodies to Mycoplasma pulmonis. Histopathologically, the mycoplasma positive SHR rats were observed to have the typical pulmonary lesions which are characterized by the hyperplasia of the lymphoid tissue around the bronchi, bronchioles and vessels. Based on the histopathological findings and serological results, this case was diagnosed as a murine mycoplasmosis of SHR rats.

Key Words: SHR, M. pulmonis, Mycoplasmosis