Korean Journal of Veterinary Research 2002;42(1):21-28.
Immunohistochemical study of the pancreatic endocrine cells in the ICR mice
Sae-kwang Ku1, Hyeung-sik Lee2, Jae-hyun Lee3
1Pharmacology & Toxicology Lab., Central Research Laboratories, Dong-Wha Pharm. Ind. Co.
2Department of Biology, Faculty of Natural Sciences, Kyungsan University
3Department of Histology, College of Veterinary Medicine, Kyungpook National University
ICR 마우스 췌장 내분비세포에 대한 면역조직화학적 연구
구세광1, 이형식2, 이재현3
1동화약품 (주) 중앙연구소 약리독성연구실
2경산대학교 자연과학부 생물학과
3경북대학교 수의과대학 조직학교실
The regional distribution and relative frequency of the pancreatic endocrine cells in the ICR mouse were studied by immunohistochemical (PAP) method using four types of specific antisera against insulin, glucagon, somatostatin and human pancreatic polypeptide (PP). The pancreas of mice could be divided into three portions; pancreatic islets, exocrine and pancreatic ducts. Pancreatic islets, furthermore, were subdivided into three regions (central, mantle and peripheral region) according to their located types of immunoreactive cells. In the pancreatic islet portions, insulin-immunoreactive cells were located in the central and mantle regions but most of somatostatin-, glucagon- and PP-immunoreactive cells were detected in the mantle and peripheral regions with various frequencies. In addition, PP-immunoreactive cells were also found in the central regions of pancreatic islets of ICR mouse. In the exocrine portions, all four types of immunoreactive cells were demonstrated in the ICR mouse. In the pancreatic duct portions, insulin- and glucagon-immunoreactive cells were situated in the epithelial lining of ICR mouse with a few and rare frequencies, respectively. In addition, rare PP-immunoreactive cells were also demonstrated in the subepithelial regions of the pancreatic duct. However, no somatostatin-immunoreactive cells were demonstrated.
Key Words: ICR mouse, pancreatic endocrine cell, immunohistochemistry

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