Effects of whole-body gamma-irradiation on the peripheral blood of ICR mouse

Kim, Sung-Ho; Lee, Jong-Hwan; Kim, Se-Ra; Lee, Hae-June; Lee, Yun-Sil; Kim, Tae-Hwan; Ryu, Si-Yun; Jo, Sung-Kee; An, Mi-Yeong

Korean Journal of Veterinary Research 2002;42(2):183-190.

Sung-Ho Kim¹, Jong-Hwan Lee¹, Se-Ra Kim¹, Hae-June Lee¹, Yun-Sil Lee², Tae-Hwan Kim², Si-Yun Ryu³, Sung-Kee Jo⁴, Mi-Yeong An⁵

¹College of Veterinary Medicine, Chonnam National University
²Korea Cancer Center Hospital
³College of Veterinary Medicine, Chungnam National University
⁴Korea Automic Energy Research Institute
⁵College of Veterinary Medicine, Texas A&M University

ICR 마우스에서 방사선 조사 용량에 따른 혈액변화의 관찰

김성호¹, 이종환¹, 김세라¹, 이해준¹, 이윤실², 김태환², 류시윤³, 조성기⁴, 안미영⁵

¹전남대학교 수의과대학
²한국원자력병원
³충남대학교 수의과대학
⁴한국원자력연구소
⁵Texas A&M University 수의과대학

Abstract

The effects of ionizing radiation on the peripheral blood elements of ICR mouse were examined after varying doses of whole-body gamma-irradiation. ICR mice (n=50) were exposed to 0, 2, 4, 6 and 8 Gy gamma-ray ($^{60}Co$) at 10 Gy/min. The animals were studied for their hematological response on days, 3, 7, 14, 21, 42 and 56 post irradiation. No significant change was noted in erythrocyte, hemoglobin and hematocrit values after irradiation with dose of 2 Gy. Decreasing erythrocyte, hemglobin and hematocrit values occured after irradiation with doses of more than 4 Gy on day 7 after irradiation followed by a sharp fall on day 14. A recovery in these values was noted after 3 weeks of irradiation. Thrombocyte counts decreased on day 3, reaching minimal values on day 7. The total number of leukocytes was reduced on day 3, mainly because of a decrease in the lymphocyte population. An evident lymphopenia and neutropenia occur almost on the day 3 and last up to the day 28 after irradiation. All of the hematological values decreased in the blood in a dose-dependent manner at the same time.

Key Words: gamma-radiation, peripheral blood, ICR mouse