Effects of whole-body gamma-irradiation on the peripheral blood of ICR mouse |
Sung-Ho Kim1, Jong-Hwan Lee1, Se-Ra Kim1, Hae-June Lee1, Yun-Sil Lee2, Tae-Hwan Kim2, Si-Yun Ryu3, Sung-Kee Jo4, Mi-Yeong An5 |
1College of Veterinary Medicine, Chonnam National University 2Korea Cancer Center Hospital 3College of Veterinary Medicine, Chungnam National University 4Korea Automic Energy Research Institute 5College of Veterinary Medicine, Texas A&M University |
ICR 마우스에서 방사선 조사 용량에 따른 혈액변화의 관찰 |
김성호1, 이종환1, 김세라1, 이해준1, 이윤실2, 김태환2, 류시윤3, 조성기4, 안미영5 |
1전남대학교 수의과대학 2한국원자력병원 3충남대학교 수의과대학 4한국원자력연구소 5Texas A&M University 수의과대학 |
|
Abstract |
The effects of ionizing radiation on the peripheral blood elements of ICR mouse were examined after varying doses of whole-body gamma-irradiation. ICR mice (n=50) were exposed to 0, 2, 4, 6 and 8 Gy gamma-ray ($^{60}Co$) at 10 Gy/min. The animals were studied for their hematological response on days, 3, 7, 14, 21, 42 and 56 post irradiation. No significant change was noted in erythrocyte, hemoglobin and hematocrit values after irradiation with dose of 2 Gy. Decreasing erythrocyte, hemglobin and hematocrit values occured after irradiation with doses of more than 4 Gy on day 7 after irradiation followed by a sharp fall on day 14. A recovery in these values was noted after 3 weeks of irradiation. Thrombocyte counts decreased on day 3, reaching minimal values on day 7. The total number of leukocytes was reduced on day 3, mainly because of a decrease in the lymphocyte population. An evident lymphopenia and neutropenia occur almost on the day 3 and last up to the day 28 after irradiation. All of the hematological values decreased in the blood in a dose-dependent manner at the same time. |
Key Words:
gamma-radiation, peripheral blood, ICR mouse |
|