Korean Journal of Veterinary Research 2002;42(3):321-326.
Involvement of Nitric Oxide and Prostanoid on Photorelaxation in Pig Renal Artery
Joo-Heon Kim1, Cheol-Soo Shim1, Seok-Cheol Jeon2
1College of Veterinary Medicine, Gyeongsang National University and Institute of Animal Medicine
2Cardiac center, Mason Samsung General Hospital Masan
UV-light 에 의한 혈관 이완작용에 있어서 nitric oxide와 prostanoid의 관련성
김주헌1, 심철수1, 전석철2
1경상대학교 수의과대학, 동물의학연구소
2마산삼성병원 심장센터
Abstract
The effect of nitric oxide synthase(NOS) inhibita, $N^G$-nitro-L-arginine-methyl ester(L-NAME) and prostanoid synthesis inhibiter, indomethacin on the photorelaxation, when was exposed to the long-wave length UV-light, was examined on the precontraction by the phenylephrine in the isolated pig renal artery. 1. UV-light relaxed both with-endothelium and without-endothelium in the pig renal arterial ring contracted by the phenylephrine. The magnitude of photorelaxation was dependent on the exposure time for UV-light. 2. UV-Iight induced relaxation was inhibited by L-NAME and indomethacin on the precontraction by the phenylephrine in the isolated pig renal artery. 3. UV-Iight induced relaxation was inhibited by methylene blue on the precontraction by the phenylephrine in the isolated pig renal artery. These results suggest that UV-light induced photorelaxation may be due to cGMP involved both nitric oxide and prostanoid on the precontraction by the phenylephrine in the isolated pig renal artery.
Key Words: Photorelaxation, L-NAME, indomethacin, methylene blue, renal artery


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