Korean Journal of Veterinary Research 2002;42(3):429-436.
A case of Hydrocephalus in S/D Rat with the Closure of Mesencephalic Aqueduct
Ik-Hyun Cho1, Kyu-Bo Han2, Byung-Joon Chang1
1College of Veterinary Medicine, Konkuk University
2Samsung Veterinary Hospital
중뇌수도관 폐쇄에 의한 S/D계통 랫드 수뇌증 1예
조익현1, 한규보2, 장병준1
1건국대학교 수의과대학
2삼성종합동물병원
Abstract
Hydrocepbalus may be an acquired or a congenital condition. We have studied the macroscopic and microscopic changes in the hydrocephalus of an inbred Sprague-Dawley rat at postnatal week 8. The animal suspected with the hydrocephalus showed clinical syndromes such as depression, severe ataxia, eye abnormalities, dome-shaped head, and persistent fontanelle. With the postmortem examination, the suspected animal was clearly revealed as a severe internal hydrocephalus. In this animal, severe ventriculomegaly was limited to the third and lateral ventricles, and cortical thining was most apparent in the parieto-occipital region. With the routine histological examination, brain tissue showed aqueductal obstruction, thinning of the cerebral cortex, severe ependymal damage, subependymal edema, damage of choroid plexus of fourth ventricle, enlarged cortical vessels, and expanded ventricles. Aqueductal obstruction was observed with the appearance of simple stenosis at the level of rostral colliculus. Subsequently, the other structures of brain such as septal nucleus, caudate nucleus, and hippocampus etc. were abnormally reconstructed by hydrocephalus. This study suggests that the hydrocephalus can be taken place by primary aqueductal obstruction and this type of hydrocephalus is classified as uncommunicating type. Though the mechanism of aqueductal obstruction is not clear, the morphological studies of this case may be helpful for the further study of hydrocephalus.
Key Words: Sprague-Dawley rat, spontaneous, mesencephalic aqueduct, hydrocephalus
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