Evaluation on the radioprotective effect of Korean favorite teas |
Se-Ra Kim1, Hae-June Lee1, Heon Oh1, Jin-Hee Lee1, Hu-Kyung Kim1, Tae-Hwan Kim2, Sung-Kee Jo3, Sung-Ho Kim1 |
1College of Veterinary Medicine, Chonnam National University 2Korea Cancer Center Hospital 3Korea Atomic Energy Research Institute |
한국인 기호 차류의 방사선 장해 경감효과 평가 |
김세라1, 이해준1, 오헌1, 이진희1, 김휴경1, 김태환2, 조성기3, 김성호1 |
1전남대학교 수의과대학 2한국원자력병원 3한국원자력연구소 |
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Abstract |
We performed this study to determine the effect of Korean favorite teas (green tea, ginseng tea, coffee and barley tea) on jejunal crypt survival, endogenous spleen colony formation and apoptosis in jejunal crypt cells of mice irradiated with high and low dose of ${gamma}$-radiation. Jejunal crypts were protected by pretreatment of green tea (P.O.: 1.25% water extract, for 7 days before irradiation., I.P.: 50 mg/kg of body weight, at 12 and 36 hours before irradiation, p<0.01) or ginseng (I.P.: 50 mg/kg of body weight, at 12 and 36 hours before irradiation, p<0.05). Green tea (p<0.05) or ginseng (p<0.05) administration before irradiation (I.P. at 12 and 36 hours before irradiation) resulted in an increase of t formation of endogenous spleen colony. The frequency of radiation-induced apoptosis was also reduced by pretreatment of green tea (P.O.: p<0.005, I.P.: p<0.05), pretreatment of ginseng (P.O.: p<0.005, I.P.: p<0.005) or posttreatment of ginseng (I.P.: 50 mg/kg of body weight, at 30 minutes after irradiation, p<0.05). Treatment with coffee or barley tea showed no significant modifying effects on the radiation-induced damages. These results indicated that green tea and ginseng might be a useful radioprotector, especially since it is a relatively nontoxic natural product. Further studies are needed to characterize better the promotion nature of green tea, ginseng and its components. |
Key Words:
Green tea, Ginseng, Coffee, Barley tea, Radiation, Intestine, Spleen |
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