Korean Journal of Veterinary Research 2003;43(1):49-55.
The effect of Phyllostachys nigra var. henenis Strapf leaf extract in the gamma-irradiated mice
Dong-Ho Shin1, Jong-Choon Kim1, Se-Ra Kim1, Heon Oh1, In-Chul Park1, Ki-Seok Oh1, Hee-Jong Chung2, Jong-Sik Jang3, Sung-Ho Kim1
1College of Veterinary Medicine, Chonnam National University
2College of Agriculture and Life Science, Chonnam National University
3Department of Animal Science, Sangju National University
방사선 조사 마우스에서 분죽(Phyllostachys nigra var. henenis Strapf)잎 추출물의 효과
신동호1, 김종춘1, 김세라1, 오헌1, 박인철1, 오기석1, 정희종2, 장종식3, 김성호1
1전남대학교 수의과대학 수의학과
2전남대학교 농업생명과학대학 응용생물공학부
3상주대학교 축산학과
Abstract
This study was performed to determine the effect of Phyllostachys nigra var. henenis Strapf leaf extract on jejunal crypt survival, endogenous spleen colony formation and apoptosis in jejunal crypt cells of mice irradiated with high and low dose of gamma-radiation. Phyllostachys nigra var. henenis Strapf administration before irradiation (I.P.: 125 mg/kg of body weight, at 24 hours before irradiation) resulted in an increase of the formation of endogenous spleen colony (p<0.01). The frequency of radiation-induced apoptosis was also reduced by pretreatment of Phyllostachys nigra var. henenis Strapf (I.P.: 280 mg/kg or 28 mg/kg of body weight, at 24 hours before irradiation, p<0.01). These results indicated that Phyllostachys nigra var. henenis Strapf might be a useful radioprotector, especially since it is a relatively nontoxic natural product. Further studies are needed to characterize better the promotion nature of Phyllostachys nigra var. henenis Strapf and its components.
Key Words: Phyllostachys nigra var. henenis Strapf, radiation, apoptosis, spleen colony
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