| Antimicrobial effects of β-lactamase inhibitor/β-lactam antibiotics on staphylococcal mastitis |
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Suk-Kyung Lim1, Jae-Hhyang Lim2, Yi-Seok Joo1, Jin-San Moon1, Ae-Ri Lee3, Hong-Bum Koh2 |
1National Veterinary Research & Quarantine Service
2Research Institute of Veterinary Medicine, Chonnam National University
3Sangmyung University |
| Staphylococcus aureus에 의한 유방염에 대한 β-lactamase 저해제/β-lactam계 항균제 치료 효과 |
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임숙경1, 임재향2, 주이석1, 문진산1, 이애리3, 고홍범2 |
1국립수의과학검역원
2전남대학교 동물의학연구소
3상명대학교 |
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| Abstract |
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The antimicrobial effect of ${eta}$-lactam antibiotics, which had ${eta}$-lactamase inhibitor activity, on Staphylococcus aureus isolated from mastitis was investigated in this study. Out of 166 isolates, 99 isolates (59.6%) produced ${eta}$-lactamase, and 98 isolates of 99 were ${eta}$-lactamase positive in above $12.5{mu}g/m{ell}$ MIC of penicillin. In the providence distribution, ${eta}$-lactamase production rate of 4 providence, Gangwon, Gyeonggi, Chungcheong, and Jeolla was 100%, 65.7%, 58.8%, and 50.0%, respectively. Antibiotic activities of ${eta}$-lactam antibiotics against lactamase positive isolates also were investigated. Antimicrobial effects of ampicillin/sulbactam or amoxicillin/clavulanic acid treated group were better than ampicillin or amoxicillin treated group. In antimicrobial effects on intracellular S aureus, there was no difference 1 hour and 4 hour treatment in control, ampicillin, and amoxicillin group, but in 18 hours treatment, ampicillin/sulbactam or amoxicillin/clavulanic acid had a better effect than ampicillin or amoxicillin (p<0.05). |
| Key Words:
${eta}$-lactam, ${eta}$-lactam inhibitor, lactamase, Staphylococcus aureus, mastitis, antimicrobial |
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