Korean Journal of Veterinary Research 2003;43(2):171-180.
The Changes of the Respiratory Organ after Inhalation of Na2CrO4¡¤4H2O in Rat
Kyoung-youl Lee1, Il-kwon Park1, Mi-sun Park1, Chi-won Song1, Mi-young Lee1, Hyun-young Kim2, Moo-kang Kim1
1Department of Histology, College of Veterinary Medicine, Chungnam National University
2Occupational Safety & Health Research Institute
Na2CrO4·4H2O를 흡입한 랫드의 호흡기 조직변화에 관한 연구
이경열1, 박일권1, 박미선1, 송치원1, 이미영1, 김현영2, 김무강1
1충남대학교 수의과대학 조직학교실
2산업안전보건연구원
Abstract
Certain hexavalent chromium compounds when administered via inhalation have the potential to induce lung injury in human and experimental animals. In present study, the inhalation effect of hexavalent chromium on morphological change and weight change of rat organ were investigated. Rats were exposed to hexavalent chromium ($Na_2CrO_4{cdot}4H_2O$) at concentration of $0.36mg/m^3$ (group 1), $1.8mg/m^3$ (group 2), ascorbic acid and $1.8mg/m^3$ (group 3) and filtered air (group 0, control group) for I week, 2 weeks and 3 weeks. The weight of lung and kidney in group 2 and group 3 significantly higher than in control group at same exposure period. The epithilial cells of bronchiole in group 1, 2, 3 were more flatten than group 0. In the lung, the number of macrophage was significantly increased and morphologically changed macrophages were observed in group 1, 2, 3. The morphological change of the lung did not significant between group 2 and group 3, however, in group 1 was milder than in group 2 and group 3. The severity of morphological change were depend on exposure period in the lung. The morphological changes by hexavalent chromium of the liver and kidney were also observed These results suggest that inhalation of hexavalent chromium effects on not only respiratory organ, but also the liver and the kidney via blood stream.
Key Words: $NaCrO_4$, respiratory organ, alveolar macrophage, rat
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