Korean Journal of Veterinary Research 2003;43(2):255-261.
Antigenicity Study of Nonspecific Immunostimulator BARODON?
Eun-hye Jo, Sung-dae Cho, Nam-shik Ahn, Ji-won Jung, Se-ran Yang, Joon-suk Park, Ki-su Park, In-sun Hong, Min-su Seo, Nguyeu Ba Tiep, Yong-soon Lee, Kyung-sun Kang
Department of Veterinary Public Health College of Veterinary Medicine, Seoul National University
비특이 면역증강제 BARODON?의 항원성시험
조은혜, 조성대, 안남식, 정지원, 양세란, 박준석, 박기수, 홍인선, 서민수, , 이영순, 강경선
서울대학교 수의과대학 공중보건학교실
The antigenicity of nonspecific immunostimulator BARODON$^{(R)}$, a newly developed drug, was investigated by tests for passive cutaneous anaphylaxis (PCA) and active systemic anaphylaxis (ASA) in mice and guinea pigs. In ASA test using guinea pigs, there were no significant clinical symptoms in all individuals of low(0.3%) and high(3%) dose of both groups treated with only BARODON$^{(R)}$ and cotreated with BARODON$^{(R)}$ and adjuvant group. In PCA test, blue spots of Evan's were observed from $2^6$ to $2^{10}$ in homologous group and from $2^2{sim}2^5$ dilution rate in heterologous group of BSA treated positive control group. However, intradermal sensitization with antiserum obtained from low (0.3%) and high (3%) dose of BARODON$^{(R)}$ only treatment group and treated-with-adjuvant group, followed by intravenous injection of respective antigen and Evan's blue mixture (1:1) showed no blue spot observed. In conclusion, BARODON$^{(R)}$, as showed in ASA and PCA test, did not cause anaphylatic shock when treated 3 and 10 times higher than clinically intended dose, nor induce IgE, so that might not have antigenic properties in mice and guinea pigs.
Key Words: passive cutaneous anaphylaxis (PCA), active systemic anaphylaxis (ASA), guinea pig, C57BL/6 mouse, BARODON$^{(R)}$
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