Korean Journal of Veterinary Research 2003;43(2):271-281.
Pathogenesis of Hong Kong H5N1 Influenza Virus in Immunodeficient Mice
Chun-ho Park
Laboratory of Comparative Pathology, Graduate School of Veterinary Medicine, Hokkaido University
Hong Kong H5N1 인플루엔자 바이러스의 면역부전 마우스에 대한 병리발생
박천호
북해도대학교 수의과대학
Abstract
Virulent and avirulent H5N1 viruses were inoculated intranasally to BALB/c and immunodeficient mice, and compared the pathogenesis by histology and immunohistochemistry. All of mice infected with virulent virus died by systemic infection at 6 to 7 days postinfection (PI). BALB/c mice infected with avirulent virus survived from the infection, whereas immunodeficient mice showed nervous symptoms in addition to respiratory disease and died at 13 days PI. Viral positive antigens was detected from multiple organs including central nervous system in immunodeficient mice infected with avirulent virus. These results suggest that avirulent H5N1 influenza virus can aquire the multiple tissue tropism under immunosuppresed condition and host immune system is a important factor to protect the development of disease.
Key Words: Pathogenesis, H5N1 influenza virus, immunodeficient mice
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