| Extracellular signal regulated kinases in the spinal cord of rats with experimental autoimmune encephalomyelitis |
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Mee-jung Ahn1, Seung-dam Heo1, Young-heun Jee1, Hong-gu Joo1, Yong-duk Lee1, Ki-Bum Sim2, Tae-kyun Shin1 |
1Department of Veterinary Medicine, College of Agriculture and Life Sciences, Cheju National University
2Department of Neurosurgery, College of Medicine, Cheju National University |
| 자기면역성 뇌척수염 조직에서 extracellular signal regulated kinases의 발현 |
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안미정1, 허승담1, 지영흔1, 주홍구1, 이용덕1, 심기범2, 신태균1 |
1제주대학교 농업생명과학대학 수의학과
2제주대학교 의과대학 신경외과학교실 |
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| Abstract |
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The phosphorylation of extracellular signal-regulated kinases (p-ERK) in the spinal cord of rats with acute monophasic experimental autoimmune encephalomyelitis (EAE) was studied using immunohistochemistry and treatment with inhibitor. P-ERK is constitutively expressed in glial cells in the normal spinal cord. In EAE, some inflammatory cells in the subarachnoid space were positive for p-ERK at the early stage, and its immunoreactivity declined when those cells infiltrated the parenchyma at the peak stage. In a blocking experiment using its inhibitor, the intravenous administration of PD98059 from day 7 to 13 post-immunization did not modulate EAE paralysis. Considering the results, we postulate that intravenous administration of PD98059 is not effective in ameliorating EAE paralysis, although many inflammatory cells express ERK in the subarachnoid space. |
| Key Words:
autoimmune encephalomyelitis, extracellular signal-regulated kinases, spinal cord |
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