Expression and localization of endothelial and inducible nitric oxide synthase in bovine uterus |
Yongduk Lee, Seungjoon Kim, Changjong Moon, Taekyun Shin |
Department of Veterinary Medicine, College of Agriculture and Life Sciences, Cheju National University |
소 자궁에서 endothelial nitric oxide synthase(NOS) 및 inducible NOS의 발현 |
이용덕, 김승준, 문창종, 신태균 |
제주대학교 농업생명과학대학 수의학과 |
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Abstract |
Nitric oxide synthase (NOS) has been reported in uterus. We examined the expression of the NOS isoforms, constitutive endothelial (eNOS) and inducible NOS (iNOS), in bovine uterus by immunohistochemistry. eNOS immunoreactivity was localized predominantly to the endothelial cells that line uterine microvessels and to endometrial glandular epithelial cells, but was barely detectable in endometrial stromal cells. iNOS immunostaining was detected in glandular epithelial and stromal cells in the endometrium and in the endothelial cells of myometrial blood vessels. These findings suggest that both eNOS and iNOS may play important roles in the physiology of the uterus, possibly by generating NO. |
Key Words:
bovine, nitric oxide synthase, uterus |
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