Korean Journal of Veterinary Research 2003;43(4):579-585.
Correlation between microsomal lipid peroxidation levels and drug metabolizing enzymes in rats on various ages
Jong-Hoo Cho1, DaeWoo Hwang2, Sang-Youel Park1
1Bio-Safety Research Institute, College of Veterinary Medicine, Chonbuk National University
2SungBo Science Tech.
연령증가에 따른 마이크로솜 막지질 과산화수준의 변화와 해독효소계의 관계
조종후1, 황대우2, 박상열1
1전북대학교 수의과대학, 생체안정성연구소
2(주)성보사이언스텍
Abstract
The studies were carried out on the correlation between microsomal lipid peroxidation level and drug metabolizing enzyme activities in rat liver microsomal suspensions on various ages (2-week-old, 2, 4, 8, and 12-month-old). The lipid peroxidation levels of liver homogenates tended to be elevated in a 4-month-old rat livers, but it was a little decreased in 8 and 12-month-old rat livers. The lipid peroxidation levels of microsomal suspension was not shown any significant differences by ages. Lipid peroxidation levels and microsomal cytochrome P450 and NADPH-cytochrome c reductase activity showed a direct correlation (r=0.72 and r=0.64), respectively. The activities of cytochrome P450-dependent aminopyrine-N-demethylase and benzpyrene hydroxylase in rat liver microsomes were increased by ages up to 8-month-old rats and maintained in 12-month-old rats. The correlation between lipid peroxidation levels and these cytochrome-dependent enzyme activities showed a high direct correlation (r=0.97 and r=0.81), respectively.
Key Words: microsome, cytochrome P450, drug metabolizing enzymes
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