Korean Journal of Veterinary Research 2003;43(4):657-666.
Embryo lethality and teratogenicity of 2-Bromopropane in the Sprague-Dawley rat
Jong-Choon Kim1, Ki-Seok Oh1, Dong-Ho Shin1, Sung-Ho Kim1, Hyeon-Yeong Kim2, Hyo-In Yun3, Cheng-Zhe Jiang4, Jeong-Doo Heo4, Moon-Koo Chung4
1College of Veterinary Medicine, Chonnam National University
2Industrial Chemicals Research Center, Industrial Safety and Health Research Institute, Korea Industrial Safety Corporation
3College of Veterinary Medicine, Chungnam National University
4Korea Institute of Toxicology, KRICT
Sprague-Dawley 랫드에서 2-Bromopropane의 배자치사 및 최기형성 효과
김종춘1, 오기석1, 신동호1, 김성호1, 김현영2, 윤효인3, 강성철4, 허정두4, 정문구4
1전남대학교 수의과대학
2한국산업안전공단 산업안전보건연구원 산업화학물질연구센터
3충남대학교 수의과대학
4한국화학연구원 부설 안전성평가연구소
The present study was undertaken to evaluate the potential adverse effects of 2-BP on pregnant dams and embryo-fetal development after maternal exposure during the gestational days (GD) 6 through 19 in Sprague-Dawley rats. The test chemical was administered subcutaneously to pregnant rats at dose levels of 0, 375, 750 and 1250 mg/kg/day. During the test period, clinical signs, mortality, body weights and food consumption were examined. All dams were subjected to caesarean section on GD 20 and their fetuses were examined for external, visceral and skeletal abnormalities. At above 750 mg/kg, toxic effects including signs of toxicity, suppressed body weight, decreased gravid uterine weight and reduced food intake were observed in pregnant dams. An increase in the fetal deaths, a decrease in the litter size, a reduction in the fetal body weight and an increase in the incidence of fetal morphological alterations were also found. There were no adverse effects on either pregnant dams or embryo-fetal development at a dose level of 375 mg/kg. These results suggest that a 14-day subcutaneous dose of 2-BP is embryolethal and teratogenic at above 750 mg/kg/day in pregnant rats. In the present experimental condition, the no-observed-adverse-effect level of 2-BP is considered to be 375 mg/kg/day for dams and embryo-fetuses, respectively.
Key Words: 2-bromopropane, maternal toxicity, developmental toxicity, teratogenicity, rats

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