Korean Journal of Veterinary Research 2003;43(4):703-708.
Effects of carboxymethyl chitosan fabric and low molecular weight heparin on reducing adhesion formation in the rat
Young-sam Kwon, Kwang-ho Jang
College of Veterinary Medicine, Kyungpook National University
Rat에서 carboxymethyl chitosan fabric과 low molecular weight heparin의 유착방지 효과
권영삼, 장광호
경북대학교 수의과대학
Abstract
This study was carried out to compare the efficacy of carboxymethyl chitosan fabric (CMCF) with that of the combination of low molecular weight heparin (LMWH) and CMCF for the prevention of postoperative adhesions in the rat. Adhesions were induced by suturing both the ileal serosa and peritoneum scraped until petechial bleeding occurred. CMCF were sutured between two surfaces, and LMWH were instilled intraperitoneally immediately before closure of the peritoneomuscular layer. The adhesions were blindly assessed 2 weeks later by using a tensiometer. The mean tensile strength(Newton) of formed adhesions was $2.59{pm}0.85$ in control group, $2.10{pm}0.75$ in the CMCF group and $1.53{pm}0.44$ in the CMCF+LMWH group. The most favorable prevention against adhesion was achieved in the CMCF+LMWH group. Therefore, we could conclude that CMCF+LMWH were effective in prevention against postoperative adhesion in the rat.
Key Words: carboxymethyl chitosan fabric, low molecular weight heparin, adhesion, rat


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