Korean Journal of Veterinary Research 2004;44(2):201-206.
Jong-hwan Lim1, Byoung-yong Lim1, Byung-kwon Park1, Myong-seok Kim1, Beom-su Jang1, Seung-chun Park2, Hyo-in Yun1
1College of Veterinary Medicine, Chungnam National University
2College of Veterinary Medicine, Kyungpook National University
Comparative pharmacokinetics of norfloxacin-glycine acetate after single oral administration and medication with drinking water in broilers
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Abstract
Norfloxacin (NFX) is a fluorquinolone antibacterial agent with a high antimicrobial activity and might have great potential for treating common infections in poultry. The objective of this study was to obtain comparative pharmacokinetic data after a single oral administration and medication with drinking water of norfloxacin-glycine acetate (NFX-GA) at the dose rate of 10 mg/kg bw in broilers. Fifty minutes following oral administration of NFX-GA, serum concentrations peaked at $1.32{mu}g/mL$ (range $1.03-1.45{mu}g/mL$). Serum concentration of NFX declined with a half-life of $7.21{pm}1.81$ h. On the third day after administration of medicated drinking water, steady-state was reached, with mean concentrations of NFX of $0.70{pm}0.35{mu}g/mL$. The concentration of NFX after medication of NFX-GA with drinking for 3 days provides sufficient levels to obtain maximum therapeutic effects and maintains the serum persistence of concentration exceeding MIC.
Key Words: Norfloxacin, LC/MS, oral administration, broiler, drinking water
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