Quantitative Doppler echocardiography during Dobutamine stress test in canine mitral regurgitant model

Choi, Hojung; Won, Sungjun; Lee, Kichang; Choi, Mincheol; Yoon, Junghee

Korean Journal of Veterinary Research 2004;44(2):317-322.

Hojung Choi¹, Sungjun Won², Kichang Lee², Mincheol Choi², Junghee Yoon²

¹Petfriends Animal Hospital
²College of Veterinary Medicine, Seoul National University

Abstract

This study was performed to evaluate echocardiographic parameters in dogs with experimental mitral regurgitation subjected to dobutamine stress testing. In 8 beagle dogs, a 4-prong grasping forceps was inserted into the left ventricle through the carotid artery with fluoroscopic guidance. The disruption of chordae or mitral valve leaflet was performed. Echocardiographic protocols included quantitative Doppler echocardiography and M-mode measurement for evaluating left ventricle function. After all measurement was obtained at rest, dobutamine was infused incrementally. In stress testing, all measurement also was performed at rest as the same method. In stress Doppler echocardiography, regurgitant fraction and aortic stroke volume was increased significantly (P<0.001). Effective regurgitant orifice and regurgitant volume was not changed. In M-mode examination, fractional shortening was increased significantly at stress test (P<0.001). From the results obtained in this study, it could be suggested that dobutamine stress echocardiography increase left ventricle performance in non-functional mitral regurgitation and quantitative Doppler echocardiography is non-invasive, accurate method in valvular regurgitation.

Key Words: echocardiography, Doppler, Dobutamine, mitral regurgitation, dog