| Expression of galectin-3 in the spinal cords of Lewis rats andNOD mice with experimental autoimmune encephalomyelitis |
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Heechul Kim1, Hong-Gu Joo1, Changjong Moon1, Meejung Ahn1, Youngheun Jee1, Yoon-kyu Lim1, Chang-Sung Koh2, Taekyun Shin1 |
1Department of Veterinary Medicine, College of Agriculture and Life Sciences, Cheju National University
2Department of Biomedical Laboratory Sciences, School of Health Sciences, Shinshu University |
| 자기면역성뇌척수염 척수조직에서 galection-3의 발현 |
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김희철1, 주홍구1, 문창종1, 안미정1, 지영흔1, 임윤규1, 고창성2, 신태균1 |
1제주대학교 농업생명과학대학 수의학과
2 |
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| Abstract |
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The aim of this study was to evaluate the expression of galectin-3, one of beta-galactoside-binding proteins, in the experimental autoimmune encephalomyelitis(EAE) model of Lewis rats or non-obese diabetic (NOD) mice. Western blot analysis showed that galectin-3 was weakly expressed in the spinal cords of complete Freund's adjuvant(CFA) immunized control rats. In EAE, however, galectin-3 expression was significantly increased at the peak stage(days 14 post-immunization), while it was decreased slightly at the recovery stage(day 21 post-immunization). Immunohistochemical analysis showed that galectin-3 was detected in some macrophages in demyelinating lesions of NOD mice, while galectin-3 was immunoreacted in some inflammatory cells in the perivascular cuffing in rat EAE lesions. Collectively, it is postulated that the expression of galectin-3 is significantly increased in response to neuroimmunological stimulation in the central nervous system, whereas it is weak in normal rats and mice. |
| Key Words:
galectin-3, experimental autoimmune encephalomyelitis, macrophage, animal model |
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