| The effect of calcium administration on the blood coagulationmechanism during heparin infusion |
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Il-ryong Kim1, Gon-hyung Kim2, Byungsun Kim3, Young-min Yun1, Kyoung-kap Lee1 |
1Department of Veterinary Medicine, Cheju National University
2National University of Singapore
3Korea Racing Assocoation |
| 헤파린 투여 중 칼슘 투여가 혈액응고 기전에 미치는 영향 |
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김일룡1, 김근형2, 김병선3, 윤영민1, 이경갑1 |
1제주대학교 농과대학 수의학과
2싱가포르대학
3한국마사회 |
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| Abstract |
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This study was performed to investigate the effects of calcium administration on the blood coagulation mechanism through APTT in the calf. Five male calves (70~90 kg) were used in this experiment. In the control group, heparinized normal saline (1 IU/kg/min) had been infusing into the jugular vein for 100 minutes. For the analysis of calcium effects on the APTT, the same solutions had been infusing during the first 40 minutes, subsequently the solution including calcium gluconate (3.3 mg/ml/min) had been infusing for 60 minutes. Blood samples were serially collected every 10 minutes for the APTT and platelets count and every 20 minutes for the calicum level during the infusion. In the calcium-treated group, after 70 minutes the APTT ratio (APTT heparin/APTT baseline) was higher than the therapeutic range. APTT was significantly increased at 50, 60 and 70 minutes in the calcium-treated group as compared to the control group (p<0.01). In the control group, calcium level was decreased significantly after heparin infusion (p<0.01). The platelet count was gradually decreased without significant variation in the both control and calcium-treated groups. These results suggested that APTT is slightly increased in combined heparin and calcium administration. |
| Key Words:
heparin, calcium gluconate, APTT, platelet count, calf |
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