| Effect of scan-bio laser therapy on arthropathy in rabbits |
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Hyung-Jin Cho1, Young-Su Kim1, Dong-Min Oh1, Kyung-Mi Sim1, Seong-Soo Kang1, Sung-Chul Lim2, Yong-Seong Cho3, Soo-Han Lee3, Seok-Hwa Choi4, Chun-Sik Bae1 |
1College of Veterinary Medicine, Biotechnology Research Institute, Chonnam National University
2Department of Pathology and Research Center for Resistant Cells, Chosun University, Medical School
3College of Veterinary Medicine, Konkuk University
4College of Veterinary Medicine, Chungbuk National University |
| 토끼의 관절병증에 미치는 SCAN-BIO 레이저의 치료효과 |
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조형진1, 김영수1, 오동민1, 심경미1, 강성수1, 임성철2, 조용성3, 이수한3, 최석화4, 배춘식1 |
1전남대학교 수의과대학 및 생물공학연구소
2조선대학교 의과대학 및 내성세포연구센터
3건국대학교 수의과대학
4충북대학교 수의과대학 |
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| Abstract |
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For the induction of arthropathy, 4% hydrogen peroxide ($H_2O_2$) was injected for 4 weeks into the intra-articular space of the 25 New Zealand white rabbits to damage articular cartilage. The verification of arthropathy induction and the effect of scan-bio laser treatment were determined by measuring superoxide dismutase (SOD) activity, by observing gross and histopathologic findings. The SOD activity increased by about 40% in arthropathy group, as compared to controls. Although SOD activity in arthropathy group was not significantly different from the 2-week group, it was significantly different from the 4-week control and treatment groups. There was also a significant difference between the 4-week control and treatment groups. Grossly, erosions formed on the articular cartilage surface, and the lateral femoral condyle was damaged in arthropathy group. In comparison, there was slight, but not significant, progression of the lesion in the 2-week control group, and no difference between the 2-week treatment and control groups. Conversely, severe erosions damaged the articular cartilage in the 4-week control group. Cartilage proliferation was seen in gross observations in the 4-week treatment group, suggesting a treatment effect. Histopathologically, there was slight articular surface damage and apoptosis in arthropathy group, and serious cartilage damage, despite slight chondrocyte proliferation, in the 4-week control group. By contrast, the 4-week treatment group showed chondrocyte replacement, with close to normal articular cartilage on the articular surface. There was significant cartilage proliferation with regeneration of the articular cartilage on the articular surface in the group treated with low-level laser, as compared to control group, when arthropathy was induced by $H_2O_2$ injections. Therefore, low-level laser was effective in the treatment of chemically induced arthropathy. |
| Key Words:
Arthropathy, laser, superoxide dismutase activity, rabbit |
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