Korean Journal of Veterinary Research 2004;44(4):487-495.
A comparative study on the osteoporotic animal models in ddY mouse: ovariectomized and neurectomized models
Hyeung-sik Lee1, Pyo-one Hong1, Se-kwang Ku2, Jae-hyun Lee3, Tae-Su Ham4
1Department of Herbal Biotechnology, Daegu Haany University
2Pharmacology & Toxicology Lab., Central Research Laboratories
3Department of Histology, College of Veterinary Medicine, Kyungpook National University
4College of Natural Resources, Yeungnam University
ddY 마우스를 이용한 골다공증 모델에 대한 비교연구: 난소적출 및 신경절단 모델
이형식1, 홍표원1, 구세광2, 이재현3, 함태수4
1대구한의대학교 한방생명자원학과
2동화약품(주) 중앙연구소 약리독성연구실
3경북대학교 수의과대학 조직학교실
4영남대학교 자연자원대학 생물자원학부
In order to compare the induced time of osteoporosis between ovariectomized and neurectomized models in ddY mice. Experimental groups were divided into Sham, ovariectomized (OVX group) and neurectomized (NX group) group. The changes of body weight, tibia weight and histomorphometry of epiphyseal regions of tibia that were generally used as criteria index in osteoporosis, were evaluated at 2 and 4 weeks after operations with other generally used index-changes of serum osteocalcin. Also, calcium and phosphorus levels in the ash tibia were demonstrated with their ratio (Ca/P ratio). From the result of this study, evidences which reflect osteoporotic states of animals such as decrease of absolute and relative tibia weight, histomorphometrical index of epiphyseal region of tibia including trabecular bone volume %, and calcium and phosphorous contents in tibia, were generally detected from 4 weeks after ovariectomy and 2 weeks after neurectomy with increase of serum osteocalcin levels. In conclusion, it is considered that more rapid and favorable osteoporosis was induced in neurectomized model compared to that of ovariectomized model.
Key Words: Ovariectomy, neurectomy, ddY mouse, osteoporosis, comparative study
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