Korean Journal of Veterinary Research 2004;44(4):523-532.
Evaluation of maternal toxicity in rats exposed to the insecticide amitraz during pregnancy
Jin-Young Shin1, Ki-Suk Oh1, Dong-Ho Shin1, Sung-Ho Kim1, Hyoung-Chin Kim2, Seung-Chun Park3, Hyun-Sook Lee4, Moon-Koo Chung4, Jong-Choon Kim1
1College of Veterinary Medicine, Chonnam National Universiyt
2Korea Research Institute of Bioscience and Biotechnology
3College of Veterinary Medicine, Kyungpook National University
4Korea Institute of Toxicology, KRICT
임신 중 살충제 amitraz에 노출된 랫드의 모독성 평가
신진영1, 오기석1, 신동호1, 김성호1, 김형진2, 박승춘3, 이현숙4, 정문구4, 김종춘1
1전남대학교 수의과대학
2한국생명공학연구원
3경북대학교 수의과대학
4한국화학연구원 부설 안전성평가연구소
Abstract
The present study was carried out to investigate the potential adverse effects of amitraz on pregnant dams after maternal exposure during the gestational days (GD) 1 through 19 in Sprague-Dawley rats. The test chemical was administered orally to pregnant rats at dose levels of 0, 3, 10, or 30 mg/kg/ day. During the test period, clinical signs, mortality, body weights, food consumption, serum biochemistry, gross findings, organ weights and reproductive findings on GD 20 were examined. In the 30 mg/kg group, an increase in the incidence of abnormal clinical signs and death, a suppression in the body weight gain, and a decrease in the food consumption were observed. A decrease in the liver weight and increases in the kidneys, adrenal glands and heart weights were also found. Serum biochemical investigations revealed increases in the aspartate aminotransferase (AST), total bilirubin, and chloride. In addition, an increase in the fetal death and decreases in the litter size and fetal body weight were seen at caesarean section. Inthe 10 mg/kg group, an increase in the incidence of abnormal clinical signs, decreases in the food consumption and liver weight, increases in the total bilirubin and chloride, and a decrease in the fetal body weight were observed. There were no adverse effects on clinical signs, mortality, body weights, food consumption, serum biochemistry, gross findings, organ weights and reproductive findings in the 3 mg/kg group. Based on the results, it was concluded that the 19-day repeated oral dose of amitraz to pregnant rats caused increases in the clinical signs, kidneys, adrenal glands and heart weights, AST, total bilirubin and chloride and decreases in the body weight gain, food consumption and liver weight at the dose levels of above 10 mg/kg/day. Under the present experimental conditions, the no-observed-adverse-effect level (NOAEL) of amitraz was considered to be 3 mg/kg/day.
Key Words: amitraz, insecticide, maternal toxicity, serum biochemistry, pregnant rats
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