Pulmonary adenocarcinoma with brain metastasis in a Miniature Pincher

Kang, Min-Soo; Kwon, Hyo-Jung; Park, Mi-Sun; Youn, Hwa-Young; Han, Man-Gil; Kim, Dae-Yong

Korean Journal of Veterinary Research 2004;44(4):621-624.

Min-Soo Kang, Hyo-Jung Kwon, Mi-Sun Park, Hwa-Young Youn, Man-Gil Han, Dae-Yong Kim

College of veterinary Medicine and School of Agricultural Biotechnology, Seoul National University

미니어쳐 핀셔에서 신경증상을 동반한 폐션암

강민수, 권효정, 박미선, 윤화영, 한만길, 김대용

서울대학교 수의과대학 농생명공학사업단

Abstract

A 13-year-old female Miniature Pincher was euthanized after suffering from respiratory insufficiency and seizure. At necropsy, firm tan masses approsimately 4 to 5 cm in diameter were noted at the right caudal love and left cranial lobe of the lung. On cross sections of the cerebellum and the verebrum, several compressive firm round masses, 0.5 to 1 cm in diameter, were noted. similar looking nodules were also present in the mediastinal lymph nodes. Histopathologically, the neoplastic masses consisted of cuboidal shape epithelial cells that form glandular structure. The neoplastic cells have hyperchromatic nuclei with prominent nucleoli and moderate amount of cytoplasm. The degree of mitosis was high (4-6/400X). Multiple areas of necrosis, hemorrhage, and tumor emboli were also noted. Metastasis to the mediastinal lymph nodes, pancreas, and brain was confirmed. Based on the gross and histopathologic examinations, a diagnosis of primary metastatic pulmonary adenocarcinoma was made. Clinicaly recognized neurological signs were therefore due to brain metastasis.

Key Words: Dog, lung tumor, metastasis, brain