Korean Journal of Veterinary Research 2004;44(4):663-668.
Effect of hyaluronic acid on prevention of adhesion in rats
Jong hoon Lee1, Joo Myoung Lee1, Young min Yun1, Tae young Kang1, Ho choon Woo1, Yoon ho Kang1, Nam joong Kim2, Hee seok Kim1, Kyoung kap Lee1, Jongtae Cheong1
1Department of Veterinary Medicine, Cheju National University
2Department of Companion Animal Science, HyeChon College
랫드에서 hyaluronic acid에 의한 유착 방지 효과에 관한 연구
이종훈1, 이주명1, 윤영민1, 강태영1, 우호춘1, 강윤호1, 김남중2, 김희석1, 이경갑1, 정종태1
1제주대학교 수의학과
2혜천대학 애완동물자원과
Abstract
This study was conducted to investigate the effect of hyaluronic acid (HA) on prevention of abdominal adhesions depending on various concentrations thereof by inducing an abrasion experimentally in the cecum of rats. Each group was consisted of 10 rats, and 40 rats were divided into 4 groups comprising the saline treatment group, HA 0.4% treated group, 0.6% treated group, and 0.8% treated group. And abrasion was caused in the cecum by using dry gauze and thereby, adhesion was induced. On 7 days after the operation, adhesions of each region were evaluated into the range of 0-4. Significant difference was found in the adhesion score between the control group and each experimental group (P<0.05). Also, HA 0.4% treatment group showed the lowest adhesion score (P<0.05). In the light of the above results, HA 0.4% solution was more effective on prevention of adhesion than HA 0.6% and 0.8% solution.
Key Words: cecum, adhesion, abrasion, hyaluronic acid(HA)


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