The effect of green tea on ultraviolet B-induced sunburn cell production in the skin of hairless mouse

Kim, Sung-ho; Kim, Se-ra; Lee, Hae-june; Lee, Jin-hee; Kim, Yu-jin; Kim, Jong-choon; Jang, Jong-sik; Jo, Sung-kee

Korean Journal of Veterinary Research 2005;45(1):1-6.

Sung-ho Kim¹, Se-ra Kim¹, Hae-june Lee¹, Jin-hee Lee¹, Yu-jin Kim¹, Jong-choon Kim¹, Jong-sik Jang², Sung-kee Jo³

¹College of Veterinary Medicine, Chonnam National University
²Department of Animal Science, Sangju National University
³Food Irradiation Team, Korea Atomic Energy Research Institute

자외선 B 조사 hairless 마우스에서 일광화상세포 발생 억제에 대한 녹차의 효과

김성호¹, 김세라¹, 이해준¹, 이진희¹, 김유진¹, 김종춘¹, 장종식², 조성기³

¹전남대학교 수의과대학
²상주대학교 축산학과
³한국원자력연구소 방사선이용연구부

Abstract

In this study we assessed the influences of ultraviolet (UV) light B radiation on epidermal cells by apoptotic sunburn cell (SBC) and the effect of green tea treatment on the inhibition of SBC formation in SKH1-hr mouse. The extent of changes following $200mJ/cm^2$ (0.5 mW/sec) was studied at 0, 3, 6, 12, 18, 24, 30 or 36 hours after exposure. SBCs were recognized by 3 hours after irradiation. There was tendency to increase from 3 hours to 24 hours and decrease from then to 36 hours after irradiation. The mice that received 0, 25, 50, 100, 200, 400 or $800mJ/cm^2$ of UVB were examined 24 hours after irradiation. The SBCs were induced as the radiation dose increases from 0 to $200mJ/cm^2$. A further increase of radiation dose has little further effect. The frequency of UVB ($200mJ/cm^2$)-induced SBC formation was reduced by intraperitoneal injection of green tea extract (p<0.01).

Key Words: ultraviolet B, sunburn cell, SKH1-hr mouse, green tea