Korean Journal of Veterinary Research 2005;45(1):39-43.
Primary dermal irritation study of oregano oil in rabbits
Jin-Young Shin1, Dong-Ho Shin1, Sung-Ho Kim1, Chun-Sik Bae1, Seung-Chun Park2, Ki-Hyun Kim3, Ju-Hyun Bae4, Jong-Choon Kim1
1College of Veterinary Medicine, Chonnam National University
2College of Veterinary Medicine, Kyungpook National University
3Biomist Co.
4Korea Institute of Toxicology, KRICT
토끼에서 oregano oil의 일차 피부 자극시험
신진영1, 신동호1, 김성호1, 배춘식1, 박승춘2, 김기현3, 배주현4, 김종춘1
1전남대학교 수의과대학
2경북대학교 수의과대학
4한국화학연구원 부설 안전성평가연구소
The present study was carried out to investigate the skin irritation potential of oregano oil in rabbits. A volume of 0.5 ml of test article was applied to intact and abraded skins, respectively, for 24 h in 6 healthy male New Zealand White rabbits. Parameters measured during 72 h observation period were mortality, clinical signs, body weight changes, and local irritation. Treatment-related toxic symptoms, as evidenced by anorexia and decreased locomotor activity, were observed in all rabbits tested. Two rabbits out of the 6 total died on day 2 after the application of test article due to treatment-related toxicity. The mean body weight of test animals decreased progressively during the 72 h observation period. All animals showed very slight edema at 24 h and then recovered at 72 h. These animals also showed very slight to severe erythema and/or slight eschar formation at both 24 h and 72 h. The eschar formation induced by oregano oil was not recovered at the end of additional 11-day recovery period. Based on these results, it was concluded that a single dermal application of the undiluted oregano oil caused an increased incidence of clinical signs and death and a decrease in the body weight and showed a primary irritation index score of 2.79 indicating moderate irritation.
Key Words: oregano oil, dermal irritation study, primary irritation index, rabbits
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