| Primary dermal irritation study of oregano oil in rabbits |
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Jin-Young Shin1, Dong-Ho Shin1, Sung-Ho Kim1, Chun-Sik Bae1, Seung-Chun Park2, Ki-Hyun Kim3, Ju-Hyun Bae4, Jong-Choon Kim1 |
1College of Veterinary Medicine, Chonnam National University
2College of Veterinary Medicine, Kyungpook National University
3Biomist Co.
4Korea Institute of Toxicology, KRICT |
| 토끼에서 oregano oil의 일차 피부 자극시험 |
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신진영1, 신동호1, 김성호1, 배춘식1, 박승춘2, 김기현3, 배주현4, 김종춘1 |
1전남대학교 수의과대학
2경북대학교 수의과대학
3(주)바이오미스트
4한국화학연구원 부설 안전성평가연구소 |
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| Abstract |
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The present study was carried out to investigate the skin irritation potential of oregano oil in rabbits. A volume of 0.5 ml of test article was applied to intact and abraded skins, respectively, for 24 h in 6 healthy male New Zealand White rabbits. Parameters measured during 72 h observation period were mortality, clinical signs, body weight changes, and local irritation. Treatment-related toxic symptoms, as evidenced by anorexia and decreased locomotor activity, were observed in all rabbits tested. Two rabbits out of the 6 total died on day 2 after the application of test article due to treatment-related toxicity. The mean body weight of test animals decreased progressively during the 72 h observation period. All animals showed very slight edema at 24 h and then recovered at 72 h. These animals also showed very slight to severe erythema and/or slight eschar formation at both 24 h and 72 h. The eschar formation induced by oregano oil was not recovered at the end of additional 11-day recovery period. Based on these results, it was concluded that a single dermal application of the undiluted oregano oil caused an increased incidence of clinical signs and death and a decrease in the body weight and showed a primary irritation index score of 2.79 indicating moderate irritation. |
| Key Words:
oregano oil, dermal irritation study, primary irritation index, rabbits |
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